Apolipoproteins in Lipid Disorders: Risk Assessment and by Dr. G. M. Kostner (auth.), Dr. Maryvonne Rosseneu, Prof. Dr.

By Dr. G. M. Kostner (auth.), Dr. Maryvonne Rosseneu, Prof. Dr. Kurt Widhalm, Dr. Jochen Jarausch (eds.)

There is expanding proof for the clinicial price of the apo­ lipoprotein measurements. along with ldl cholesterol in plasma and li­ poprotein fractions, that is at the moment used as a trademark of cardiovascular chance, the dimension of the AI and B apolipopro­ teins gives you additional info concerning the sufferers' medical prestige. a number of reports express that apo B is larger and apo AI is reduce in sufferers with angiographically documented heart dis­ ease than in symptomatic sufferers with out heart disorder. in addition, discriminant research indicated that the focus of Apo AI and B in plasma are larger discriminators than lipo­ protein ldl cholesterol for making a choice on sufferers with heart disorder. In a few reviews the apo Bjapo AI ratio seems to be a extra strong predictor than person lipoproteins. In a up to date learn performed in males, apolipoproteins AI and B have been greater correlated with the severity of heart problems than HDL and cholesterol. The predictive strength of apolipoproteins might although no longer be established in all experiences and the price of apolipoprotein measurements within the box of medical chemistry continues to be debatable. this can be most likely as a result of discrepancies among the result of numerous reports, bobbing up from ameliorations within the kind of immunoassays, the shortcoming of common reference fabrics, range­ ences among examine protocols, adaptations within the number of sufferers and within the grading and interpretation of coronary lesions.

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Additional resources for Apolipoproteins in Lipid Disorders: Risk Assessment and Monitoring

Sample text

When compared to LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C), what are the advantages and disadvantages of the new methods; is there additional information on the patients' lipoprotein status? - Are there specific considerations for normal probands and for patients with metabolic disease, such as diabetes (type I and type II), hypercholesterolemia, hypertriglyceridemia and hypertension? Materials and methods All assays were performed in duplicate on a COBAS® Mira Autoanalyzer (Roche, Basie, Switzerland).

Chronic renal failure, treated either by hemodialysis or by continuous ambulatory peritoneal dialysis, is accompanied by an increase in the VLDL and LDL fractions and a decrease of the HDL lipoproteins. The apo B levels are increased and the apo AI concentrations decreased in these patients. Different types of liver disease also affect the apolipoprotein levels. Acute hepatitis decreases the apo AI and All levels due to impaired protein synthesis. In chronic hepatitis, the apo AI and All synthesis is normal, but the hepatic lipase activity is decreased.

Are there specific considerations for normal probands and for patients with metabolic disease, such as diabetes (type I and type II), hypercholesterolemia, hypertriglyceridemia and hypertension? Materials and methods All assays were performed in duplicate on a COBAS® Mira Autoanalyzer (Roche, Basie, Switzerland). For purposes of comparison, we measured apo AI and apo B by nephelometry also on a Beckman Array System (Beckman Instruments, Berkeley, CA, USA). Cholesterol and triglycerides (TG) were determined as described previously [I].

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