Basics of Blood Management, Second edition by Petra Seeber, Aryeh Shander(auth.)

By Petra Seeber, Aryeh Shander(auth.)

Content material:
Chapter 1 background and association of Blood administration (pages 1–8):
Chapter 2 body structure of Anemia and Oxygen shipping (pages 9–20):
Chapter three Anemia remedy I: Erythropoiesis?Stimulating brokers (pages 21–35):
Chapter four Anemia treatment II: Hematinics (pages 36–50):
Chapter five development elements (pages 51–66):
Chapter 6 Fluid administration (pages 67–80):
Chapter 7 Chemistry of Hemostasis (pages 81–99):
Chapter eight Recombinant Blood items (pages 100–108):
Chapter nine man made Blood (pages 109–123):
Chapter 10 Oxygen treatment (pages 124–138):
Chapter eleven coaching of the sufferer for surgical procedure (pages 139–159):
Chapter 12 Iatrogenic Blood Loss (pages 160–172):
Chapter thirteen actual tools of Hemostasis (pages 173–190):
Chapter 14 Anesthesia—More than dozing (pages 191–200):
Chapter 15 Use of Autologous Blood (pages 201–211):
Chapter sixteen mobilephone Salvage (pages 212–228):
Chapter 17 Blood?Derived prescribed drugs (pages 229–244):
Chapter 18 Transfusion medication (pages 245–261):
Chapter 19 step-by-step to an equipped Blood administration software (pages 262–284):
Chapter 20 legislations, Ethics, faith, and Blood administration (pages 285–296):

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Extra resources for Basics of Blood Management, Second edition

Example text

RHuEPO is effective in increasing the hemoglobin level [14]. • Anemia associated with acquired immunodeficiency syndrome (AIDS): Anemia is common among patients with AIDS. , zidovudine). rHuEPO can be used to reverse the anemia developing in AIDS patients [52]. • Malignancy: rHuEPO is useful when dealing with anemia in cancer patients [53]. Anemia may develop due 29 to an inhibition of erythropoiesis by cytokines, blood loss, and/or hemolysis. In addition, chemotherapy induces anemia due to myelosuppression or nephrotoxicity.

Novel erythropoiesis stimulating agents: A new era in anemia management. Clin J Am Soc Nephrol 2008;3:200–207. 62. Brunkhorst R, Bommer J, Braun J, et al. Darbepoetin alfa effectively maintains haemoglobin concentrations at extended dose intervals relative to intravenous or subcutaneous recombinant human erythropoietin in dialysis patients. Nephrol Dial Transplant 2004;19:1224–1230. 63. Schwartzberg LS, Yee LK, Senecal FM, et al. A randomized comparison of every-2-week darbepoetin alfa and weekly epoetin alfa for the treatment of chemotherapy-induced anemia in patients with breast, lung, or gynecologic cancer.

RHuEPO is biologically active and reacts in a way similar to the natural hormone purified from urine. To date, several forms of rHuEPO are commercially available: EPO alpha, EPO beta, and EPO omega. They have slightly different carbohydrate residues but are equally effective in stimulating erythropoiesis. In addition, so-called “biosimilars” are emerging. These are generic compounds typically produced after the patent rights of the original products have expired. Anticipated reduced costs will hopefully result from the introduction of these chemically produced agents.

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