Burkitt’s Lymphoma by Ian Magrath (auth.), Erle S. Robertson (eds.)

By Ian Magrath (auth.), Erle S. Robertson (eds.)

The research of Burkitt’s lymphoma is now in its 6 decade starting with its discovery through Dr. Dennis Burkitt in equatorial Africa within the mid to overdue 1950’s. a wide physique of data is accessible which gives a present realizing of the underlying molecular adjustments which are associated with the initiation and improvement of Burkitt’s lymphoma. This proposed quantity will supply a complete view of Burkitt’s Lymphoma from the analysis to power animal versions for this disorder and comprise a view from physicians who've a up shut view of the sufferers in populations the place the affliction is rampant. we think that this may be an exceptional source for scientific scholars and school in addition to expert laypersons who've anyone curiosity within the disease.

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Limited sets of antibodies have been proposed for economical immunophenotyping of BL for use with suspended cells from aspirates, blood, bone marrow, tumors aspirates, or tissue cell suspensions by FC or for IHC using 6 m cut tissue sections (Fig. 5). BL has surface IgM and Ig light chain antigens, leukocyte antigens CD45, CD43; B-cell lineage 2 Diagnosis of Burkitt Lymphoma 43 Fig.

Magrath 33. Ramiro AR, Jankovic M, Callen E et al (2006) Role of genomic instability and p53 in AIDinduced c-myc-Igh translocations. Nature 440(7080):105–109 34. Jankovic M, Robbiani DF, Dorsett Y et al (2010) Role of the translocation partner in protection against AID-dependent chromosomal translocations. Proc Natl Acad Sci USA 107(1):187–192 35. Gaidano G, Ballerini P, Gong JZ et al (1991) p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.

Epstein MA, Achong BG, Barr YM (1964) Virus particles in cultured lymphoblasts from Burkitt’s lymphoma. Lancet 1(7335):702–703 44. Schulte-Holthausen H, zur Hausen H (1972) Epstein–Barr virus DNA in human tumor cells. Zentralbl Bakteriol Orig A 220(1):47–51 45. Reedman BM, Klein G (1973) Cellular localization of an Epstein–Barr virus (EBV)associated complement-fixing antigen in producer and non-producer lymphoblastoid cell lines. Int J Cancer 11:499–520 46. Young LS, Rickinson AB (2004) Epstein–Barr virus: 40 years on.

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