Chemokine Receptors as Drug Targets (Methods and Principles by Martine J. Smit, Sergio A. Lira, Rob Leurs, Raimund

By Martine J. Smit, Sergio A. Lira, Rob Leurs, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

Starting with a basic creation on chemokine functionality and chemokine receptor biology, the guide is going directly to disguise the identified implications of those signaling molecules in human illnesses, reminiscent of melanoma, neural issues, and viral an infection, together with HIV/AIDS. the second one 1/2 the booklet systematically surveys present drug improvement efforts at focusing on person chemokine receptors, in addition to different chemokine interplay companions. Contributions within the first a part of the publication are commonly from academia, while the second one half includes up to date experiences from the pharmaceutical undefined.

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Extra resources for Chemokine Receptors as Drug Targets (Methods and Principles in Medicinal Chemistry)

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And Clark-Lewis, I. (2001) The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3. The Journal of Biological Chemistry, 276, 2986–2991. J. (2000) C-C chemokine receptor 3 antagonism by the betachemokine macrophage inflammatory protein 4, a property strongly enhanced 16 17 18 19 20 21 22 by an amino-terminal alaninemethionine swap. Journal of Immunology (Baltimore, Md: 1950), 164, 1488–1497. W. (1998) Selective recognition of the membrane-bound CX3C chemokine, fractalkine, by the human cytomegalovirus-encoded broadspectrum receptor US28.

The Journal of Biological Chemistry, 273, 33157–33165. J. (2000) CC chemokine MIP-1 beta can function as a monomer and depends on Phe13 for receptor binding. Biochemistry, 39, 3401–3409. N. (1997) Glycosaminoglycans mediate cell surface oligomerization of chemokines. Biochemistry, 36, 13570–13578. G. (1999) Aggregation of RANTES is responsible for its inflammatory properties. Characterization of nonaggregating, noninflammatory RANTES mutants. The References 52 53 54 55 56 57 58 Journal of Biological Chemistry, 274, 27505–27512.

2005) Proteolytic activation of alternative CCR1 ligands in inflammation.

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