By J. S. Brazier, S. P. Borriello (auth.), Professor Dr.Dr. Klaus Aktories, Dr. Tracy D. Wilkins (eds.)
Clostridium difficile has been famous because the reason for a extensive spectrum of enteric ailment starting from gentle antibiotic-associated diarrhea to pseudomembranous colitis. This quantity offers new insights into the microbiology, diagnostics and epidemiology of Clostridium difficile and describes contemporary techniques in therapy of illnesses brought on by this agent. major components of the quantity are dedicated to Clostridium difficile pollution A and B that are the foremost virulence components. The molecular biology, biochemistry, pharmacology and cellphone biology of those pollution that are the prototypes of a brand new kin of huge clostridial cytotoxins is defined in nice aspect. Clostridium difficile pollution act as glucosyltransferases to inactivate small GTP-binding proteins of the Rho relatives that are fascinated with rules of the actin cytoskeleton, mobile adhesion and numerous signaling processes.
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Additional resources for Clostridium difficile
BAPS Health Publication Unit , Heywood Lancashire Depitre C. Delmec M, Avesani V. L'Haridon R. Roels A. Popoff M , Corthier G (1993) Serogroup F strains of ClostridiulII dilficile produce toxin B but not toxin A. J Med Microbiol 38:434- 441 Devlin HR, Au W. Foux L. Bradhury WC (1987) Restriction endonuclease analysis of nosocomial isolates of ClostridiulII difficile. J Clin Microbiol 25:2168- 2172 Donta ST. Myers MG (I 9X2) ClostridiulII diffide toxin in asymptomatic neonates. J Pediatr 100:43 1-434 EI Mohandes AE.
Lysates of recombinant E. coli expressing the toxin A gene contained the cytotoxic activity, enterotoxic activity, and lethal properties associated with toxin A (PHELPS et al. 1991 ). Chromosomal walking experiments used for cloning the toxin A gene led directly to cloning of the toxin B gene (JOHNSON et al. 1990). The 3' end of the toxin B gene turned out to be located 1350bp upstream of the toxin A initiation codon. 2kb of DNA which, when subcloned , expressed a nontoxic peptide that reacted with toxin B antibodies.
Johnson S. Jansen Pc. Opstad NL. Bettin KM, Gerding DN (1996) Protein-losing enteropathy is associated with Clostridiul1I di/ftci/e diarrhea but not with asymptomatic colonization: a prospective. case-control study. Clin Infect Dis 22:932-937 De Girolami Pc. 1-lanfT PA. Eichelberger K, Longhi L. Teresa H, Pratt J (1992) Multicenter evaluation of a ncw enzymc immunoassay for detection of Clostridiul1I di/ftcile enterotoxin A. J Clin Microhiol 30: 1085- I 088 Delmee M. Homel M. Wauters G (1985) Serogrouping of Clostridium di/ftcile strains by slide agglutination.