Signaling Molecules: Roles in Differentiation and

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ABL gene on chromosome 9 placed next to BRC gene on 22 results in a fusion protein bcr-abl ! abl is a non-receptor Y-kinase ! bcr is member of the Rho family of small GTPases ! Similar translocation occurs in ALL CML is target of Y-kinase inhibitor Glivec Non-Hodgkin’s Lymphoma ! ! !

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